Research: Bridged azapolycycles are compounds that consist of multiple rings with a “bridging” linkage between the rings and include at least one nitrogen atom. Structural features of this type are found in many biologically active alkaloids and pharmaceuticals. Research in the Griffith lab focuses on the synthesis of bridged azapolycycles that contain a seven-membered ring, which are particularly challenging to create. As such, these types of compounds are under-represented in compound collections used in drug discovery efforts.
An active area of investigation has been the development of methods for accessing diverse, complex alkaloid-like scaffolds from a simple, seven-membered ring building block–tropone. We have found that amines with a variety of functionalized side chains can be added to the iron complex (η4-tropone)Fe(CO)3. These different functionalized side chains enables a variety of downstream reactions enabling access to diverse bridged azapolycycles. Specific examples can be found in the publications listed below.
Selected Recent Publications:
undergraduate student coauthors underlined